Bellvitge contra el parkinson i alzheimer

Un fàrmac utilitzat contra el rebuig de trasplantaments podria retardar l’Alzheimer o el Parkinson Bellvitge Un fàrmac que s’utilitza per evitar el rebuig en els trasplantaments es podria utilitzar per retardar l’aparició de malalties neurodegeneratives, com l’Alzheimer i el Parkinson. És la conclusió d’un estudi on ha participat l’Idibell, l’Institut d’Investigació Biomèdica de Bellvitge i que ara publica la revista “Nature”.

En fer les proves “in vitro” que s’han fet, els investigadors han comprovat que la Rapamicina, com es diu el medicament, permet manipular els errors en les proteïnes detonants de malalties com el Parkinson. Si bé aquest fàrmac pot retardar o protegir de l’aparició de les malalties neurodegeneratives, no permetria curar-les.

Sigui com sigui, encara s’està lluny d’una possible aplicació en pacients. Ara es mirarà de validar la teoria en animals i estudiar els efectes de la Rapamicina amb altres fàrmacs.

Coordinat per investigadors de l’International School for Advanced Studies (Sissa) de Trieste, a Itàlia, l’estudi és fruit de cinc anys de treball que es van iniciar després que van descobrir, sense saber-ne el perquè, que els pacients de Parkinson tenien un dèficit en la proteïna Uchl1.

Gràcies a un projecte europeu anomenat Dopaminet, que estudiava les cèl·lules implicades en el Parkinson, els investigadors van veure que la proteïna es regulava mútuament amb la seva proteïna mirall. Segons l’estudi, si la proteïna mirall es troba en el nucli de la cèl·lula no interacciona amb la proteïna, mentre que si és al citoplasma sí que ho fa.

En el cas del Parkinson, la proteïna Uchl1 es redueix i la seva proteïna mirall es localitza en el nucli i no en el citoplasma. Per això, els investigadors van buscar un mètode per extraure la proteïna mirall del nucli i fer-la interactuar amb la proteïna original, fet que és possible per la Rapamicina.

La investigació donada a conèixer ara ha permès descobrir un mecanisme que passa perquè la proteïna mirall d’Uchl1 que s’acumula en el nucli pugui sortir al citoplasma per unir-se a la proteïna Uchl1 i, així, interaccionin.

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