anunci.info Barcelona 324.cat Els tumors de prop del 20% dels pacients de càncer de pulmó presenten un tipus de mutació genètica que acaba fent resistència al tractament al cap d’un any de començar-lo i que fa que la malaltia continuï progressant. Ara l’Institut Català d’Oncologia ha participat en un estudi internacional que ha identificat el mecanisme que explica per què es fan resistents als fàrmacs. La descoberta obre les portes a futurs tractaments més efectius contra el càncer de pulmó, principalment contra el tipus de tumor que afecta els malalts no fumadors i les dones.
Segons explica el doctor Rafael Rosell, cap del Servei d’Oncologia de l’ICO, l’estudi descriu“un mecanisme extraordinari de resistència i la part més diabòlica del càncer”.
Rosell espera que al més aviat possible es pugui tirar endavant un assaig clínic amb pacients i que la indústria farmacèutica s’impliqui en el projecte. “És un gran descobriment i ara hem de pressionar la indústria per impulsar assajos clínics de nous fàrmacs ja que pot ser útil per a altres tumors”, ha dit.
“El càncer de pulmó era abans la Ventafocs dels tumors, el que no volia cap metge perquè tenia molt mal pronòstic, però el paradigma ha canviat perquè anem identificant les alteracions genètiques a través de la biòpsia i podem prescriure el millor fàrmac des de l’inici del tractament”, conclou l’investigador.
L’investigador explica, a més, que la descoberta és extrapolable a altres tipus de càncers, com alguns tumors de mama o de fetge.
L’estudi, que compta amb l’impuls de l’Obra Social La Caixa, l’ha publicat la revista “Nature Genetics”.
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